专利名称：Method for the manufacture of anagrelide发明人：Lang, Philip Charles,Spencer, Roxanne
Paula,Yeh, Wen-Lung,Roth, Michael Joseph
申请号：EP06013051.5申请日：20010726公开号：EP1700859A3公开日：20100224
摘要：Methods are provided for making certain 6,7-dihalo-1,5-dihydroimidazo [2,1-b]quinazolin-2 (3H)-ones from 2,3-dihalobenzaldehydes. A method is also provided formaking the intermediate ethyl N-(2,3-dihalo-6-nitrobenzyl)glycines from 2,3-dihalobenzaldehydes and for reducing the glycine compounds using either SnCl or aspecially defined catalyst. A cyclization method to form the desired 6,7-dihalo-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-ones from the corresponding iminoquinazolinecompounds is further provided. These methods are particularly suitable in themanufacture of Anagrelide base.
申请人：Shire US Inc.
地址：One Riverfront Place Newport KY 41071 US
国籍：US
代理机构：Atkinson, Jonathan David Mark
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