专利名称：Oligonucleotides and analogs labeled with
energy transfer dyes
发明人：Linda Lee,Sandra Spurgeon,Barnett
Rosenblum
申请号：US12554845申请日：20090904公开号：US07825237B2公开日：20101102
专利附图：
摘要：Novel linkers for linking a donor dye to an acceptor dye in an energy transferfluorescent dye are provided. These linkers facilitate the efficient transfer of energy
between a donor and acceptor dye in an energy transfer dye. One of these linkers forlinking a donor dye to an acceptor dye in an energy transfer fluorescent dye has thegeneral structure RZC(O)RRwhere Ris a Calkyl attached to the donor dye, C(O) is acarbonyl group, Zis either NH, sulfur or oxygen, Ris a substituent which includes analkene, diene, alkyne, a five and six membered ring having at least one unsaturated bondor a fused ring structure which is attached to the carbonyl carbon, and Rincludes afunctional group which attaches the linker to the acceptor dye.
申请人：Linda Lee,Sandra Spurgeon,Barnett Rosenblum
地址：Palo Alto CA US,San Mateo CA US,San Jose CA US
国籍：US,US,US
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