Coagulation factor X polypeptides with modified ac

专利名称：Coagulation factor X polypeptides with

modified activation properties

发明人：Stefan Schulte,Hans-Peter Hauser,Uwe

Kalina,Thomas Weimer

申请号：US11921399申请日：20060530公开号：US09249404B2公开日：20160202

摘要：The present invention relates to modified cDNA sequences coding for humanFactor X and their derivatives with improved stability and modified activation sequences,recombinant expression vectors containing such cDNA sequences, and host cellstransformed with such recombinant expression vectors. The invention also relates torecombinant factor X polypeptides and derivatives which have biological activities of theunmodified wild type protein but with improved stability and processes for the

manufacture of such recombinant proteins and their derivatives. The invention also coversa transfer vector for use in human gene therapy, which comprises such modified DNA.

申请人：Stefan Schulte,Hans-Peter Hauser,Uwe Kalina,Thomas Weimer

地址：Marburg DE,Marburg DE,Marburg DE,Gladenbach DE

国籍：DE,DE,DE,DE

代理机构：Finnegan, Henderson, Farabow, Garrett & Dunner, LLP

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