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Antibacterial compositions comprising a beta-lacta

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专利名称:Antibacterial compositions comprising a

beta-lactam-type compound and a 3-substituted propenoate

发明人:Kahan, Frederick M.,Kropp, Helmut申请号:EP80106704.2申请日:19801031公开号:EP0028778A1公开日:19810520

摘要:An antibacterial composition comprising (a) cephaloridine and a 3-substitutedpropenoate of either of the formula wherein e.g. R and R are hydrocarbon radicals; aterminal hydrogen in R can be replaced by several groups; R' is hydrogen or C-C alkyl ordialkylaminoalkyl, n is 3 to 5 and Y is heterocyclic or phenyl optionally substituted withhydroxyl, oxo, carboxyl, or methyl or (b) thienamycin, N-guanyl or N-formimidoylthienamycin and a compound of formula II. The propenoate compounds preventnephrotoxicity of the antibiotics. The antibiotic to propenoate weight ratio is from about1 to 0.1-3.

申请人:Merck & Co., Inc.

地址:126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US

国籍:US

代理机构:Abitz, Walter, Dr.-Ing.

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