Substituted imidazolyl-alkyl-piperazine and -diaze

专利名称：Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives

发明人：Pascal, Jean-Claude,Lee, Chi-Ho,Alps, Brian

J.,Pinhas, Henri,Whiting, Roger L.,Beranger,Serge

申请号：EP883036.9申请日：19880422公开号：EP02227B1公开日：19920408

摘要：Substituted imidazolyl-alkyl-piperazine and diazepine derivatives of Formula A:wherein:     R¹ is aryl;     R² is aryl, C₁₋₄ alkyl, or hydrogen;     R³ is C₁₋₄ alkyl,hydroxy, or hydrogen;     R⁴ is aryl;     R⁵ is aryl;     m is two or three;     n is zero,one or two, provided that when R³ is hydroxy, n is one or two; and     q is zero, one, two,or three; and the pharmaceutically acceptable salts thereof, are useful for treatingmammals having a variety of disease states, such as stroke, epilepsy or epileptic psychoticsymptoms, hypertension, angina, migraine, arrhythmia, thrombosis, embolism, acutecardiac failure, irritable bowel syndrome, neurodegenerative diseases such as Alzheimer'sor Huntington's chorea, diuresis, ischemia such as focal and global ischemia orcerebrovascular ischemia induced by cocaine abuse, and also for treatment of spinalinjuries.

申请人：SYNTEX PHARMACEUTICALS LTD.

地址：SYNTEX HOUSE ST. IVES ROAD; MAIDENHEAD BERKSHIRE SL6 1RD

代理机构：Armitage, Ian Michael

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