专利名称：METHODS AND COMPOSITIONS FOR THE
PRODUCTION AND USE OFMAGNETOSOMES
发明人：Xiaoping Philip Hu,Anthony Wing Sang
Chan,Omar Zurkiya
申请号：US11912817申请日：20060428
公开号：US20090311194A1公开日：20091217
专利附图：
摘要：Methods and compositions for using magnetosomes as cellular contrast agents
and markers for magnetic resonance imaging are provided. Certain methods involvesynthesizing magnetosomes in a cell as directed by a nucleotide construct comprising anexogenous polynucleotide sequence, wherein the magnetosome serves as a contrastagent or marker for magnetic resonance imaging. Methods of synthesizing and isolatingmagnetosomes for introduction into immune-matched cells within a tissue or subject foruse as a contrast agent or marker for magnetic resonance imaging are also provided.Also provided are methods for stably transfecting cells to express a polypeptide thatdrives or modulates magnetosome production in the cell, cells produced by suchmethods and methods for their isolation, transgenic animals comprising at least oneeukaryotic cell produced by such methods, and vectors and delivery systems for thetransfection of such cells. Further provided are methods for non-invasively generating avisible image of a tissue or subject containing at least one cell such transfected cell, aswell as use of such methods to monitor the location, migration, or proliferation of cells ina tissue or subject or to detect or monitor gene expression in a tissue or subject.
申请人：Xiaoping Philip Hu,Anthony Wing Sang Chan,Omar Zurkiya
地址：Tucker GA US,Norcross GA US,Boston MA US
国籍：US,US,US
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