Human antibodies to PD-1

专利名称：Human antibodies to PD-1发明人：Nicholas J. Papadopoulos,Andrew J.

Murphy,Gavin Thurston,Ella Ioffe,ElenaBurova

申请号：US14603776申请日：20150123公开号：US09987500B2公开日：20180605

摘要：The present invention provides antibodies that bind to the T-cell co-inhibitorprogrammed death-1 (PD-1) protein, and methods of use. In various embodiments of theinvention, the antibodies are fully human antibodies that bind to PD-1. In certainembodiments, the present invention provides multi-specific antigen-binding moleculescomprising a first binding specificity that binds to PD-1 and a second binding specificitythat binds to an autoimmune tissue antigen, another T-cell co-inhibitor, an Fc receptor, ora T-cell receptor. In some embodiments, the antibodies of the invention are useful forinhibiting or neutralizing PD-1 activity, thus providing a means of treating a disease ordisorder such as cancer or a chronic viral infection. In other embodiments, the antibodiesare useful for enhancing or stimulating PD-1 activity, thus providing a means of treating,for example, an autoimmune disease or disorder.

申请人：Regeneron Pharmaceuticals, Inc.

地址：Tarrytown NY US

国籍：US

代理人：Aparna G. Patankar

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