CLOSTRIDIUM DIFFICILE TOXINS A ANDOR B ANTIGEN AN

专利名称：CLOSTRIDIUM DIFFICILE TOXINS A AND/OR

B ANTIGEN AND EPITOPE ANTIBODY, ANDPHARMACEUTICAL USES THEREOF

发明人：GAUDREAU, Simon,CLOUTIER,

Martin,FORTIER, Louis-charles,LEDUC,Frederic,TREMBLAY, Maxime,VERONNEAU,Steeve,GBRIC, Djorjde,LARRIVEE, Jean-François

申请号：EP16751875.2申请日：20160219公开号：EP3271375A1公开日：20180124

摘要：It is described a Clostridium difficile (C-difficile) toxins A and/or B as a target fortherapy, including passive immunotherapy, and particularly prevention of C-difficileintoxication in human or other animals. It is also described a polypeptide comprising aportion of C-difficile toxins A and/or B sequence being an epitope for anti-toxins A and/orB antibody. It disclosed a method for generating a neutralizing antibody directed againstC-difficile toxins A and/or B. It is also provided a novel formulation that combines keytoxins A and/or B epitope antibodies, located in three key domains of toxins A and/or B,for neutralisation of the toxins A and/or B, at any stage of toxins A and/or B intoxicationrelated to C-difficile infection. The novel formulation of toxins A and/or B epitopeantibodies are useful in immunotherapy, for 10 therapeutic and/or prophylacticmediation of C-difficile intoxication.

申请人：Immune Biosolutions Inc.

地址：1497 Rue Montmartre Sherbrooke, Québec J1N 3W8 CA

国籍：CA

代理机构：Cabinet Plasseraud

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