HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS

专利名称：HETEROARYL SUBSTITUTED

AMINOPYRIDINE COMPOUNDS

发明人：DUNCIA, John V.,GARDNER, Daniel S.,HYNES,

John,MACOR, John E.,SANTELLA, JosephB.,WU, Hong,NAIR, Satheesh Kesavan,PAIDI,Venkatram Reddy,SARKUNAM,Kandhasamy,SISTLA, RameshKumar,POLIMERA, Subba Rao

申请号：EP16734832.5申请日：20160623公开号：EP3313844A1公开日：20180502

摘要：Disclosed are compounds of Formula (I) or salts thereof, wherein: HET is aheteroaryl selected from imidazo[1,2-b]pyridazinyl and pyrazolo[1,5-a]pyrimidinyl,wherein said heteroaryl is attached to the pyridinyl group in the compound of Formula (I)by a carbon ring atom in the heteroaryl and wherein said heteroaryl is substituted withzero to 2 Rb; A is pyrazolyl, imidazolyl, or triazolyl, each substituted with zero or 1 Ra;and R3, Ra, and Rb are define herein. Also disclosed are methods of using such

compounds as modulators of IRAK4, and pharmaceutical compositions comprising suchcompounds. These compounds are useful in treating, preventing, or slowinginflammatory and autoimmune diseases, or in the treatment of cancer.

申请人：Bristol-Myers Squibb Company

地址：Route 206 and Province Line Road Princeton, NJ 083 US

国籍：US

代理机构：Kling, Edouard

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